Pistachio production in Italy is an opportunity to improve the resilience of mountain production systems because it is a niche crop with high income and nutritional value, combining sustainability of agricultural territories and competitiveness of production even in marginal areas. However, the quality and food safety of pistachio is threatened by phytopathologies and fungal contamination by Aspergilli-producing mycotoxins; the latter are extremely harmful to human health. The goal of the project is to develop a systematic, digital model to manage healthy pistachio production that is scalable and transferable to mountainous areas in the north as well. The research will focus on product quality and healthiness through the development of technical protocols for the early diagnosis and sustainable control of important plant diseases and mycotoxin-producing Aspergilli in pistachio, from cultivation to storage. By integrating good production practices (bibliographic and digital questionnaire data analysis) with project protocols, technical specifications for digital field and storage notebooks will be defined. These tools, together with those of partner companies and the cloud platform for consulting data in real time, will constitute the ProMode digital system for managing healthy pistachio production. A pilot action will map potentially suitable sites for pistachio cultivation in an iNEST area.